LOCUS       X73487                   492 bp    DNA     linear   VRL 14-NOV-2006
DEFINITION  Adenovirus type 12 DNA, complete genome.
ACCESSION   X73487 REGION: 1542..2033
VERSION     X73487.1  GI:313361
KEYWORDS    complete genome; core protein; DNA polymerase; DNA-binding protein;
            endoprotease; fiber protein; hexon protein; large T-antigen;
            maturation protein; minor core protein; penton protein;
            peripentonal hexon-associated protein; promoter; repeat region;
            small t-antigen; transcriptional activation.
SOURCE      Human adenovirus 12
  ORGANISM  Human adenovirus 12
            Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Tolun,A., Alestrom,P. and Pettersson,U.
  TITLE     Sequence of inverted terminal repetitions from different
            adenoviruses: demonstration of conserved sequences and homology
            between SA7 termini and SV40 DNA
  JOURNAL   Cell 17 (3), 705-713 (1979)
   PUBMED   225041
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Sugisaki,H., Sugimoto,K., Takanami,M., Shiroki,K., Saito,I.,
            Shimojo,H., Sawada,Y., Uemizu,Y., Uesugi,S. and Fujinaga,K.
  TITLE     Structure and gene organization in the transformed Hind III-G
            fragment of Ad12
  JOURNAL   Cell 20 (3), 777-786 (1980)
   PUBMED   6251973
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Shinagawa,M. and Padmanabhan,R.
  TITLE     Comparative sequence analysis of the inverted terminal repetitions
            from different adenoviruses
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 77 (7), 3831-3835 (1980)
   PUBMED   6253991
REFERENCE   4
  AUTHORS   Kimura,T., Sawada,Y., Shinawawa,M., Shimizu,Y., Shiroki,K.,
            Shimojo,H., Sugisaki,H., Takanami,M., Uemizu,Y. and Fujinaga,K.
  TITLE     Nucleotide sequence of the transforming early region E1b of
            adenovirus type 12 DNA: structure and gene organization, and
            comparison with those of adenovirus type 5 DNA
  JOURNAL   Nucleic Acids Res. 9 (23), 6571-6589 (1981)
   PUBMED   6275367
  REMARK    (sites)
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Kimura,T.
  TITLE     Structure and sequence analysis of the transforming region E1B of
            human adenovirus type 12
  JOURNAL   Sapporo Igaku Zasshi 52, 253-267 (1983)
REFERENCE   6  (bases 1 to 492)
  AUTHORS   van Ormondt,H. and Galibert,F.
  TITLE     Nucleotide sequences of adenovirus DNAs
  JOURNAL   Curr. Top. Microbiol. Immunol. 110, 73-142 (1984)
   PUBMED   6383725
REFERENCE   7
  AUTHORS   Juttermann,R., Weyer,U. and Doerfler,W.
  TITLE     Defect of adenovirus type 12 replication in hamster cells: absence
            of transcription of viral virus-associated and L1 RNAs
  JOURNAL   J. Virol. 63 (8), 3535-3540 (1989)
   PUBMED   2746738
  REMARK    (sites)
REFERENCE   8
  AUTHORS   Zock,C., Iselt,A. and Doerfler,W.
  TITLE     A unique mitigator sequence determines the species specificity of
            the major late promoter in adenovirus type 12 DNA
  JOURNAL   J. Virol. 67 (2), 682-693 (1993)
   PUBMED   8419643
  REMARK    (sites)
REFERENCE   9
  AUTHORS   Sprengel,J., Schmitz,B., Heuss-Neitzel,D., Zock,C. and Doerfler,W.
  TITLE     Nucleotide sequence of human adenovirus type 12 DNA: comparative
            functional analysis
  JOURNAL   J. Virol. 68 (1), 379-389 (1994)
   PUBMED   8254750
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Sprengel,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-1993) J. Sprengel, Institute of Genetics/Dept.
            Virology, Weyertal 121, 50931 Cologne 41, FRG
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Human adenovirus 12"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:28282"
     promoter        <1..87
                     /note="crossref Ad12 EPD07152"
                     /function="E1b promoter region (-499 to +100)"
     CDS             1..492
                     /note="crossref SWISS-PROT:E1BS_ADE12, P04492"
                     /codon_start=1
                     /product="E1B protein, small T-antigen"
                     /protein_id="CAA51878.1"
                     /db_xref="GI:313363"
                     /db_xref="GOA:P04492"
                     /db_xref="InterPro:IPR002475"
                     /db_xref="InterPro:IPR002924"
                     /db_xref="UniProtKB/Swiss-Prot:P04492"
                     /translation="MELETVLQSFQSVRQLLQYTSKNTSGFWRYLFGSTLSKVVNRVK
                     EDYREEFENILADCPGLLASLDLCYHLVFQEKVVRSLDFSSVGRTVASIAFLATILDK
                     WSEKSHLSWDYMLDYMSMQLWRAWLKRRVCIYSLARPLTMPPLPTLQEEKEEERNPAV
                     VEK"
     variation       199
                     /citation=[5]
                     /replace="t"
     variation       201
                     /citation=[5]
                     /replace="g"
     CDS             306..>492
                     /note="crossref SWISS-PROT:E1BL_ADE12, P04491"
                     /codon_start=1
                     /product="E1B protein, large T-antigen"
                     /protein_id="CAA51879.1"
                     /db_xref="GI:313364"
                     /db_xref="GOA:P04491"
                     /db_xref="InterPro:IPR002612"
                     /db_xref="InterPro:IPR006717"
                     /db_xref="InterPro:IPR011050"
                     /db_xref="UniProtKB/Swiss-Prot:P04491"
                     /translation="MEREIPPELGLHAGLHVNAAVEGMAEEEGLHLLAGAAFDHAAAA
                     DVARGEGGGAEPCGGGEVNMEQQVQEGHVLDSGEGPSCADDRDKQEKKESLKEAAVLS
                     RLTVNLMSRPRLETVYWQELQDEFQRGDMHLQYKYSFEQLKTHWLEPWEDMECAIKAF
                     AKLALRPDCSYRITKTVTITSCAYIIGNGAIVEVDTSDRVAFRCRMQGMGPGVVGLDG
                     ITFINVRFAGDKFKGIMFEANTCLVLHGVYFLNFSNICVESWNKVSARGCTFYGCWKG
                     LVGRPKSKLSVKKCLFEKCVLALIVEGDAHIRHNAASENACFVLLKGMAILKHNMVCG
                     VSDQTMRRFVTCADGNCHTLKTVHIVSHSRHCWPVCDHNMFMRCTIHLGLRRGMFRPS
                     QCNFSHSNIMLEPEVFSRVCLNGVFDLSVELCKVIRYNDDTRHRCRQCECGSSHLELR
                     PIVLNVTEELRSDHLTLSCLRTDYESSDEDDN"
ORIGIN      
        1 atggagttgg aaactgtgct gcaaagtttt cagagcgttc gccagctctt gcagtatacc
       61 tctaaaaaca cttcaggttt ttggaggtat ctgtttggct ctaccttaag caaggtggta
      121 aatagggtga aagaagacta tagagaggaa tttgaaaaca tattggccga ctgtccaggg
      181 cttttggctt cactagacct ttgttaccac ttggtgtttc aggaaaaagt ggtcagatcc
      241 ttagattttt catctgtggg acgaacggtt gcttctattg cttttttggc aaccatattg
      301 gataaatgga gcgagaaatc ccacctgagt tgggattaca tgctggatta catgtcaatg
      361 cagctgtgga gggcatggct gaagaggagg gtttgcattt actcgctggc gcggcctttg
      421 accatgccgc cgctgccgac gttgcaagag gagaaggagg aggagcggaa ccctgcggtg
      481 gtggagaagt aa
//