LOCUS X73487 1359 bp DNA linear VRL 14-NOV-2006
DEFINITION Adenovirus type 12 DNA, complete genome.
ACCESSION X73487 REGION: 3844..5202
VERSION X73487.1 GI:313361
KEYWORDS complete genome; core protein; DNA polymerase; DNA-binding protein;
 endoprotease; fiber protein; hexon protein; large T-antigen;
 maturation protein; minor core protein; penton protein;
 peripentonal hexon-associated protein; promoter; repeat region;
 small t-antigen; transcriptional activation.
SOURCE Human adenovirus 12
 ORGANISM Human adenovirus 12
 Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus.
REFERENCE 1 (bases 1 to 114)
 AUTHORS Tolun,A., Alestrom,P. and Pettersson,U.
 TITLE Sequence of inverted terminal repetitions from different
 adenoviruses: demonstration of conserved sequences and homology
 between SA7 termini and SV40 DNA
 JOURNAL Cell 17 (3), 705-713 (1979)
 PUBMED 225041
REFERENCE 2 (bases 1 to 114)
 AUTHORS Sugisaki,H., Sugimoto,K., Takanami,M., Shiroki,K., Saito,I.,
 Shimojo,H., Sawada,Y., Uemizu,Y., Uesugi,S. and Fujinaga,K.
 TITLE Structure and gene organization in the transformed Hind III-G
 fragment of Ad12
 JOURNAL Cell 20 (3), 777-786 (1980)
 PUBMED 6251973
REFERENCE 3 (bases 1 to 114)
 AUTHORS Shinagawa,M. and Padmanabhan,R.
 TITLE Comparative sequence analysis of the inverted terminal repetitions
 from different adenoviruses
 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 77 (7), 3831-3835 (1980)
 PUBMED 6253991
REFERENCE 4
 AUTHORS Kimura,T., Sawada,Y., Shinawawa,M., Shimizu,Y., Shiroki,K.,
 Shimojo,H., Sugisaki,H., Takanami,M., Uemizu,Y. and Fujinaga,K.
 TITLE Nucleotide sequence of the transforming early region E1b of
 adenovirus type 12 DNA: structure and gene organization, and
 comparison with those of adenovirus type 5 DNA
 JOURNAL Nucleic Acids Res. 9 (23), 6571-6589 (1981)
 PUBMED 6275367
 REMARK (sites)
REFERENCE 5 (bases 1 to 18)
 AUTHORS Kimura,T.
 TITLE Structure and sequence analysis of the transforming region E1B of
 human adenovirus type 12
 JOURNAL Sapporo Igaku Zasshi 52, 253-267 (1983)
REFERENCE 6 (bases 1 to 114)
 AUTHORS van Ormondt,H. and Galibert,F.
 TITLE Nucleotide sequences of adenovirus DNAs
 JOURNAL Curr. Top. Microbiol. Immunol. 110, 73-142 (1984)
 PUBMED 6383725
REFERENCE 7 (bases 988 to 1359)
 AUTHORS Shu,L.M., Hong,J.S., Wei,Y.F. and Engler,J.A.
 TITLE Nucleotide sequence of the genes encoded in early region 2b of
 human adenovirus type 12
 JOURNAL Gene 46 (2-3), 187-195 (1986)
 PUBMED 3803925
REFERENCE 8
 AUTHORS Juttermann,R., Weyer,U. and Doerfler,W.
 TITLE Defect of adenovirus type 12 replication in hamster cells: absence
 of transcription of viral virus-associated and L1 RNAs
 JOURNAL J. Virol. 63 (8), 3535-3540 (1989)
 PUBMED 2746738
 REMARK (sites)
REFERENCE 9
 AUTHORS Zock,C., Iselt,A. and Doerfler,W.
 TITLE A unique mitigator sequence determines the species specificity of
 the major late promoter in adenovirus type 12 DNA
 JOURNAL J. Virol. 67 (2), 682-693 (1993)
 PUBMED 8419643
 REMARK (sites)
REFERENCE 10
 AUTHORS Sprengel,J., Schmitz,B., Heuss-Neitzel,D., Zock,C. and Doerfler,W.
 TITLE Nucleotide sequence of human adenovirus type 12 DNA: comparative
 functional analysis
 JOURNAL J. Virol. 68 (1), 379-389 (1994)
 PUBMED 8254750
REFERENCE 11 (bases 1 to 1359)
 AUTHORS Sprengel,J.
 TITLE Direct Submission
 JOURNAL Submitted (21-JUN-1993) J. Sprengel, Institute of Genetics/Dept.
 Virology, Weyertal 121, 50931 Cologne 41, FRG
FEATURES Location/Qualifiers
 source  1..1359
 /organism="Human adenovirus 12"
 /mol_type="genomic DNA"
 /db_xref="taxon:28282"
 CDS  complement(1..1359)
 /note="homologue to maturation protein Ad5, Ad2, Ad7;
 crossref SWISS-PROT:PIV2_ADE02, PIV2_ADE05, PIV2_ADE07"
 /codon_start=1
 /product="maturation protein (protein IVA2)"
 /protein_id="CAA51881.1"
 /db_xref="GI:313366"
 /db_xref="GOA:P12540"
 /db_xref="InterPro:IPR003389"
 /db_xref="UniProtKB/Swiss-Prot:P12540"
 /translation="MLPCRSTGRRHALQHQPPQFKAHTGQRSTRSASIHRDRNNPDAH
 ITSLEGQNPRPFGCSPPRSLQQQPAKPPQRGSLLDRDGIENITELWDRLQLLKQTLDH
 MPMADGLKPLKNFKSLQELLSLGGERLLGELAKQNIRVRQMMNEVAPLLHEDGSCTSL
 NYHLQPVIGVIYGPTGCGKSQLLRNLLSAQLVTPAPETVFFIVPQVDMIPPSEIKSWE
 MQICEGNYVPGPEGTIIPQSGTLCPKFVKLSYDDLTLDHNYDVSDPENIFAQAAARGP
 IAIIMDECMENLGSHKGVSKFFHAFPSKLHDKFPKCTGYTVFVVLHNMNPRRDLAGNI
 ANLKIQSKLHIMSPRMHPTQLNRFINTYTKGLPLAISLLLKDIFNHHAQRCCYDWIIY
 NTNPEHEALQWSYLHPKDGLMPMYLNIQAHLYKILEHIHRVLNDRERWSRAYHVRKNK
 YQ"
 misc_feature 947..1258
 /note="11.2K urf"
 variation 1014..1015
 /citation=[7]
 /replace="gc"
 variation 1036
 /citation=[7]
 /replace="c"
 variation 1042
 /citation=[7]
  /replace="c"
 CDS complement(1110..>1359)
 /note="crossref SWISS-PROT:DPOL_ADE12, P06538"
 /codon_start=1
 /product="DNA polymerase"
 /protein_id="CAA51882.1"
 /db_xref="GI:313367"
 /db_xref="GOA:P06538"
 /db_xref="InterPro:IPR004868"
 /db_xref="InterPro:IPR006134"
 /db_xref="InterPro:IPR006172"
 /db_xref="InterPro:IPR012337"
  /db_xref="UniProtKB/Swiss-Prot:P06538"
 /translation="MLFSLTDTMDSSRLYALISRFRPSRAEIWTCRSRGTVTLSVLAF
 EDPNGSGNAAEEEEDERQLPSGIDFPICFLVRGRQVHLIQQIQPVQRCEHCARFYKHQ
  HECSVRRRDFYFHHINSHSSNWWQEIHFFPIGSHPRTERLFITYDVETYTWMGAFGKQ
 LVPFMLVMKLSGDDNLVKHALQLALELGWDQWEKDSTTFYCLTPEKMKVGQQFRTYRN
 RLQTSLATDLWMTFLQKNPHLSQWAQEENGLVALEDLSYEDLKRAPAIKGEPRFVELY
  IVGHNINGFDEIVLAAQVINNRLDVPGPFKISRNFIPRAGKILFNDITFALPNPHYKK
 RTNFLLWEHGGCDDQDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCPYKAV
 NQFYMLGSYRADANGFPLEEYWKDKEEYLLNQELWKKKGEKNYNLIGETLNYCALDVL
 VTASLVEKLRSSYAQFVTDAVGLDAAHFNVFQRPTISSNSHAIFRQILYRAEKPQRTH
 LGPNILAPSHELYDYVRASIRGGRCYPTYIGVLKEPIYVYDICGMYASALTHPMPWGP
 PLNPYERALAVRQWQVALENYTCKIDYFDKNLCPGIFTIDADPPDENQLDVLPPFCSR
 KGGRLAWTNESLRGEVVTSVDLVTLHNRGWRLRLLSDERTTIFPTWKCLAREYVQLNI
 AAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMEESLMKEIAAGRLN
 IKSSSFIETDTLSTEVMPAFERVYSPNQLALVNSEAEESDEDQGPAPFYSPPPENCEH
 VTYTYKPITFMDAEEGDMCLHTLESSNPLINNDRYPSHVASFVLAWTRAFVSEWSEFL
 YEEDRGIPLKDRPLKSVYGDTDSLFVTEKGRRLMESQGKKRIKKYGGKLVFDPSCPEL
 TWSVECETVCSYCGADAYSPESVFLAPKLYALKCLQCPHCGSTSKGKIRAKGHATEAL
 SYDLMLKCYLAEAQGEDTRFSTSRLSLKRTLASAQPGAHPFTVTETTLTRTLRPWKDK
  TLVHLDAHRLVPYSNSQPNPRNEEVCWIEMA"
ORIGIN 
 1 ttattgatac ttgttttttc tgacatggta agctcttgac caccgttccc tatcattaag
 61 aacacggtga atgtgttcca gtattttgta aagatgagcc tgtatattaa ggtacattgg
 121 cattaggcca tctttgggat gaaggtagga ccattgaagg gcttcatgtt ccgggttagt
 181 gttgtagata atccagtcat agcaacaacg ctgggcatgg tgattaaata tatcttttaa
 241 caacaagcta attgctaatg gaagaccttt agtataggta ttgataaaac ggttaagctg
 301 ggtgggatgc atccgaggtg acatgatatg aagttttgat tgtattttga gattggcaat
 361 gttacctgcc aaatctcttc ttggattcat attgtggaga accacgaaaa cggtgtagcc
 421 agtacacttg ggaaatttgt catggagttt agaaggaaag gcatggaaaa acttggaaac
 481 gcctttgtga cttcccaaat tttccataca ctcatccatt attatggcaa ttggaccgcg
 541 agcagcggct tgagcaaaaa tgttttctgg atcagaaaca tcatagttgt ggtctagagt
 601 taggtcatcg taggacaact taacaaattt aggacacagc gttccagatt gtggaataat
 661 agttccctct ggtcctggga cataatttcc ctcacaaatt tgcatttccc aagatttaat
 721 ttcagatggg ggaatcatgt ccacttgcgg aacaataaaa aaaacagttt ctggagcagg
 781 tgtaaccagc tgggcagaaa gcaaattacg caacaactga gacttcccac agccagtggg
 841 tccataaatt accccaatta caggttgcaa gtgatagttt aacgaggtgc agctgccgtc
 901 ttcgtggaga agcggagcca cttcattcat catttgtcgg acgcggatgt tttgcttggc
 961 cagttcccct aacagacgct ctccgcctaa ggaaagtaac tcttgtaaag atttgaaatt
 1021 tttaagtggc tttaggccat cggccatagg catgtggtcc agggtttgct tcagcagttg
 1081 caagcgatcc catagctcag ttatattttc tatgccatct cgatccagca aacttcctcg
 1141 ttgcgggggt ttggctggct gttgctgtaa ggaacgaggc ggtgagcatc caaatggacg
 1201 agggttttgt ccttccaggg acgtaatgtg cgcgtcaggg ttgtttcggt cacggtgaat
 1261 ggatgcgctc ctggttgagc gctggccagt gtgcgcttta aactgaggcg gctggtgctg
 1321 aagcgcgtgt cttctccctg tgcttcggca aggtagcat
//