LOCUS       X73487                  3186 bp    DNA     linear   VRL 14-NOV-2006
DEFINITION  Adenovirus type 12 DNA, complete genome.
ACCESSION   X73487 REGION: 4953..8138
VERSION     X73487.1  GI:313361
KEYWORDS    complete genome; core protein; DNA polymerase; DNA-binding protein;
            endoprotease; fiber protein; hexon protein; large T-antigen;
            maturation protein; minor core protein; penton protein;
            peripentonal hexon-associated protein; promoter; repeat region;
            small t-antigen; transcriptional activation.
SOURCE      Human adenovirus 12
  ORGANISM  Human adenovirus 12
            Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus.
REFERENCE   1
  AUTHORS   Kimura,T., Sawada,Y., Shinawawa,M., Shimizu,Y., Shiroki,K.,
            Shimojo,H., Sugisaki,H., Takanami,M., Uemizu,Y. and Fujinaga,K.
  TITLE     Nucleotide sequence of the transforming early region E1b of
            adenovirus type 12 DNA: structure and gene organization, and
            comparison with those of adenovirus type 5 DNA
  JOURNAL   Nucleic Acids Res. 9 (23), 6571-6589 (1981)
   PUBMED   6275367
  REMARK    (sites)
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Shu,L.M., Hong,J.S., Wei,Y.F. and Engler,J.A.
  TITLE     Nucleotide sequence of the genes encoded in early region 2b of
            human adenovirus type 12
  JOURNAL   Gene 46 (2-3), 187-195 (1986)
   PUBMED   3803925
REFERENCE   3
  AUTHORS   Juttermann,R., Weyer,U. and Doerfler,W.
  TITLE     Defect of adenovirus type 12 replication in hamster cells: absence
            of transcription of viral virus-associated and L1 RNAs
  JOURNAL   J. Virol. 63 (8), 3535-3540 (1989)
   PUBMED   2746738
  REMARK    (sites)
REFERENCE   4
  AUTHORS   Zock,C., Iselt,A. and Doerfler,W.
  TITLE     A unique mitigator sequence determines the species specificity of
            the major late promoter in adenovirus type 12 DNA
  JOURNAL   J. Virol. 67 (2), 682-693 (1993)
   PUBMED   8419643
  REMARK    (sites)
REFERENCE   5
  AUTHORS   Sprengel,J., Schmitz,B., Heuss-Neitzel,D., Zock,C. and Doerfler,W.
  TITLE     Nucleotide sequence of human adenovirus type 12 DNA: comparative
            functional analysis
  JOURNAL   J. Virol. 68 (1), 379-389 (1994)
   PUBMED   8254750
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Sprengel,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-1993) J. Sprengel, Institute of Genetics/Dept.
            Virology, Weyertal 121, 50931 Cologne 41, FRG
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Human adenovirus 12"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:28282"
     CDS             complement(<1..250)
                     /note="homologue to maturation protein Ad5, Ad2, Ad7;
                     crossref SWISS-PROT:PIV2_ADE02, PIV2_ADE05, PIV2_ADE07"
                     /codon_start=1
                     /product="maturation protein (protein IVA2)"
                     /protein_id="CAA51881.1"
                     /db_xref="GI:313366"
                     /db_xref="GOA:P12540"
                     /db_xref="InterPro:IPR003389"
                     /db_xref="UniProtKB/Swiss-Prot:P12540"
                     /translation="MLPCRSTGRRHALQHQPPQFKAHTGQRSTRSASIHRDRNNPDAH
                     ITSLEGQNPRPFGCSPPRSLQQQPAKPPQRGSLLDRDGIENITELWDRLQLLKQTLDH
                     MPMADGLKPLKNFKSLQELLSLGGERLLGELAKQNIRVRQMMNEVAPLLHEDGSCTSL
                     NYHLQPVIGVIYGPTGCGKSQLLRNLLSAQLVTPAPETVFFIVPQVDMIPPSEIKSWE
                     MQICEGNYVPGPEGTIIPQSGTLCPKFVKLSYDDLTLDHNYDVSDPENIFAQAAARGP
                     IAIIMDECMENLGSHKGVSKFFHAFPSKLHDKFPKCTGYTVFVVLHNMNPRRDLAGNI
                     ANLKIQSKLHIMSPRMHPTQLNRFINTYTKGLPLAISLLLKDIFNHHAQRCCYDWIIY
                     NTNPEHEALQWSYLHPKDGLMPMYLNIQAHLYKILEHIHRVLNDRERWSRAYHVRKNK
                     YQ"
     misc_feature    <1..149
                     /note="11.2K urf"
     CDS             complement(1..3186)
                     /note="crossref SWISS-PROT:DPOL_ADE12, P06538"
                     /codon_start=1
                     /product="DNA polymerase"
                     /protein_id="CAA51882.1"
                     /db_xref="GI:313367"
                     /db_xref="GOA:P06538"
                     /db_xref="InterPro:IPR004868"
                     /db_xref="InterPro:IPR006134"
                     /db_xref="InterPro:IPR006172"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="UniProtKB/Swiss-Prot:P06538"
                     /translation="MLFSLTDTMDSSRLYALISRFRPSRAEIWTCRSRGTVTLSVLAF
                     EDPNGSGNAAEEEEDERQLPSGIDFPICFLVRGRQVHLIQQIQPVQRCEHCARFYKHQ
                     HECSVRRRDFYFHHINSHSSNWWQEIHFFPIGSHPRTERLFITYDVETYTWMGAFGKQ
                     LVPFMLVMKLSGDDNLVKHALQLALELGWDQWEKDSTTFYCLTPEKMKVGQQFRTYRN
                     RLQTSLATDLWMTFLQKNPHLSQWAQEENGLVALEDLSYEDLKRAPAIKGEPRFVELY
                     IVGHNINGFDEIVLAAQVINNRLDVPGPFKISRNFIPRAGKILFNDITFALPNPHYKK
                     RTNFLLWEHGGCDDQDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCPYKAV
                     NQFYMLGSYRADANGFPLEEYWKDKEEYLLNQELWKKKGEKNYNLIGETLNYCALDVL
                     VTASLVEKLRSSYAQFVTDAVGLDAAHFNVFQRPTISSNSHAIFRQILYRAEKPQRTH
                     LGPNILAPSHELYDYVRASIRGGRCYPTYIGVLKEPIYVYDICGMYASALTHPMPWGP
                     PLNPYERALAVRQWQVALENYTCKIDYFDKNLCPGIFTIDADPPDENQLDVLPPFCSR
                     KGGRLAWTNESLRGEVVTSVDLVTLHNRGWRLRLLSDERTTIFPTWKCLAREYVQLNI
                     AAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMEESLMKEIAAGRLN
                     IKSSSFIETDTLSTEVMPAFERVYSPNQLALVNSEAEESDEDQGPAPFYSPPPENCEH
                     VTYTYKPITFMDAEEGDMCLHTLESSNPLINNDRYPSHVASFVLAWTRAFVSEWSEFL
                     YEEDRGIPLKDRPLKSVYGDTDSLFVTEKGRRLMESQGKKRIKKYGGKLVFDPSCPEL
                     TWSVECETVCSYCGADAYSPESVFLAPKLYALKCLQCPHCGSTSKGKIRAKGHATEAL
                     SYDLMLKCYLAEAQGEDTRFSTSRLSLKRTLASAQPGAHPFTVTETTLTRTLRPWKDK
                     TLVHLDAHRLVPYSNSQPNPRNEEVCWIEMA"
     promoter        351..950
                     /note="crossref Ad12 (EPD26036), homologue to Ad2
                     (EPD07159), Ad5 (EPD11203), Ad7 (EPD11204)"
                     /citation=[4]
                     /function="major late promoter region (-499 to +100)"
     misc_feature    494..781
                     /note="10.6K urf"
     variation       513
                     /citation=[2]
                     /replace="t"
     promoter        complement(539..1137)
                     /note="homologue to promoter IVa2 Ad2 (EPD07156), Ad5
                     (EPD11200), Ad7 (EPD11201)"
                     /function="promoter region IVa2"
     variation       592
                     /citation=[2]
                     /replace="g"
     TATA_signal     819..826
                     /note="TATA box of the major late promoter (MLP)"
     misc_RNA        849
                     /note="cap site for late mRNA transcripts"
     misc_feature    1169..1201
                     /citation=[4]
                     /function="regulatory element +320 to +352 nt downstream
                     of the major late promoter"
     variation       1462
                     /citation=[2]
                     /replace="g"
     variation       1804..1805
                     /citation=[2]
                     /replace="gc"
     variation       1969
                     /citation=[2]
                     /replace="g"
     variation       2627
                     /citation=[2]
                     /replace=""
     variation       2636
                     /citation=[2]
                     /replace="c"
     CDS             2650..>3186
                     /note="unnamed protein product; DNA-binding protein;
                     homologue to crossref SWISS-PROT:DNBI_ADE02, DNBI_ADE07"
                     /codon_start=1
                     /protein_id="CAA51883.1"
                     /db_xref="GI:313368"
                     /db_xref="GOA:P36704"
                     /db_xref="UniProtKB/Swiss-Prot:P36704"
                     /translation="MFDKIVIPRQFHHQHKWDKLLSKCPHPGVGFYIIGNKKALSARM
                     RTDWEKVDLLPPVGRMAVDVMKVEISSADRAFMLMFVKACAVFASLHGLYLLNEVYLA
                     ASHQKADGKINTTWQLPFVLFLFCCIATTVWILESENGEGDGAPRPACPDFSTRGAET
                     GNQGVQPGAVHGISQREKHVRGDSAQVDFAQAGKSRLEVQVILNF"
     variation       2703
                     /citation=[2]
                     /replace="g"
     misc_feature    complement(2742..3032)
                     /note="10.6K urf"
     misc_feature    2939..>3186
                     /note="11.7K urf"
     variation       3091
                     /citation=[2]
                     /replace="g"
ORIGIN      
        1 ctatgccatc tcgatccagc aaacttcctc gttgcggggg tttggctggc tgttgctgta
       61 aggaacgagg cggtgagcat ccaaatggac gagggttttg tccttccagg gacgtaatgt
      121 gcgcgtcagg gttgtttcgg tcacggtgaa tggatgcgct cctggttgag cgctggccag
      181 tgtgcgcttt aaactgaggc ggctggtgct gaagcgcgtg tcttctccct gtgcttcggc
      241 aaggtagcat tttaacataa gatcataaga caaagcctct gtagcgtggc ctttagcccg
      301 tatttttcct ttggaggtgc tcccgcagtg aggacactga aggcatttaa gggcgtacag
      361 ttttggagcc aaaaaaacag attctggaga ataagcatct gcgccacaat aactacaaac
      421 agtttcacat tcaactgacc aggtcagctc aggacatgat ggatcaaaaa caagtttccc
      481 tccgtacttt ttgatgcgtt tcttaccttg cgactccata aggcggcgtc ctttctctgt
      541 gacaaaaaga ctgtcagtgt ctccgtatac agatttaagg ggtctatcct tcagtggtat
      601 tccgcggtcc tcctcgtaca ggaattctga ccactctgac acaaaagctc tagtccaagc
      661 aagtacaaag gaagccacat gggaagggta ccgatcgttg ttaattaaag ggttagaact
      721 ttctaaggtg tgtaaacaca tgtctccttc ttcagcgtcc atgaatgtga ttggtttgta
      781 ggtgtaagtc acgtgttcac aattttctgg tggtgggcta taaaaagggg cgggtccttg
      841 gtcttcatcg ctttcttctg cttcgctgtt tacgagcgcc aactggttgg gtgagtacac
      901 gcgctcaaag gcaggcatta cctctgtact caacgtgtca gtttctataa acgatgagga
      961 tttgatgttt aatcgccccg ctgcaatttc tttcattagg ctttcttcca tttgatcaga
     1021 aaaaactatt tttttgttat ctagtttggt agcaaaagat ccgtacaagg cattggaaag
     1081 cagcttggct atagatctta gggtttgatt tttgtcccta tcggcccgtt cttttgcggc
     1141 aatattgagt tgcacatatt cgcgtgccag gcatttccag gtggggaaaa tggtggtgcg
     1201 ctcgtcagat agcaagcgta agcgccaccc gcgattatgc agtgtaacca gatctacgct
     1261 ggtaactact tcaccgcgca agctttcatt ggtccaggct aaacgaccgc cttttctaga
     1321 acaaaaagga ggaagaacat ccaactgatt ttcatctggg gggtcggcat ctatagtaaa
     1381 aatgccagga caaagatttt tgtcaaaata atcaattttg caagtgtaat tttccagcgc
     1441 cacctgccat tgccgcacgg ccaatgcccg ctcatagggg ttaaggggag gaccccaagg
     1501 catggggtgt gtgagggccg atgcatacat gccgcaaata tcatatacat atatgggctc
     1561 ttttagtact cctatgtaag taggatagca cctgccgcca cgaatgctgg cgcgaacgta
     1621 gtcatatagc tcatgtgaag gcgccaggat gttgggccca agatgtgtgc gctgtggttt
     1681 ttcggcgcgg tacaaaattt gtctgaaaat tgcatgagag ttagaggaaa tggtaggacg
     1741 ctgaaacaca ttaaaatgtg ccgcgtcaag acccactgcg tcagtaacaa actgggcgta
     1801 tgagctacgc agtttttcta ccaatgaggc agtcacaagt acatccaggg cacaatagtt
     1861 taatgtttcc ccgataagat tgtaattttt ttctcctttt tttttccata gttcttgatt
     1921 taggaggtat tcctccttat ccttccagta ctcctccagg ggaaacccat ttgcatctgc
     1981 acggtaagaa ccaagcatat aaaactgatt taccgccttg tacggacaac atcctttttc
     2041 tacaggcagg gcatacgctt gtgcagcctt tcttaaagat gtatgagtaa gagcaaaggt
     2101 atctctgacc attactttta aatactggta tttaaaatct tggtcgtcac accctccgtg
     2161 ttcccacagt aggaagttag ttcgcttttt gtagtgggga ttgggaaggg caaaagtaat
     2221 atcattaaat aatattttgc cagctcttgg aataaaattt ctagaaattt taaagggtcc
     2281 agggacgtcc aagcggttat tgattacctg agcggcaaga acaatttcat caaatccatt
     2341 aatattgtgt cctactatat acaactctac aaatcttggc tcacccttaa ttgcaggggc
     2401 tcttttaaga tcttcgtagg aaagatcttc aagcgcgact agtccgtttt cttcttgagc
     2461 ccattgagac aagtgtggat ttttttgtaa aaaagtcatc caaagatcag tagctaagga
     2521 ggtttgtaag cggtttctat aggtacgaaa ctgttgaccg accttcattt tttctggggt
     2581 taagcagtag aaagtagtag agtctttttc ccattggtcc catccaagtt ctaatgcaag
     2641 ttgtaaggca tgtttgacaa gattgtcatc cccagacagt ttcatcacca gcataaatgg
     2701 gacaagttgc tttccaaatg cccccatcca ggtgtaggtt tctacatcat aggtaataaa
     2761 aaggcgctca gtgcgaggat gcgaaccgat tgggaaaaag tggatctcct gccaccagtt
     2821 ggaagaatgg ctgttgatgt gatgaaagta gaaatctcgt cggcggacag agcattcatg
     2881 ctgatgtttg taaaagcgtg cgcagtgttc gcatcgttgc acgggctgta tctgttgaat
     2941 gaggtgtacc tggcggcctc gcaccagaaa gcagatggga aaatcaatac cacttggcag
     3001 ctgccgttcg tcctcttcct cttctgctgc attgccacta ccgtttggat cctcgaaagc
     3061 gagaacggag agggtgacgg tgcccctcga cctgcatgtc cagatttcag cacgagaggg
     3121 gcggaaacgg gaaatcaggg cgtacagcct ggagctgtcc atggtatcag tcagagagaa
     3181 aagcat
//