LOCUS       AY128640                 543 bp    DNA     linear   VRL 12-DEC-2003
DEFINITION  Human adenovirus type 35 strain Holden, complete genome.
ACCESSION   AY128640 REGION: 1611..2153
VERSION     AY128640.2  GI:38196041
KEYWORDS    .
SOURCE      Human adenovirus 35
  ORGANISM  Human adenovirus 35
            Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus.
REFERENCE   1  (bases 1 to 543)
  AUTHORS   Gao,W., Robbins,P.D. and Gambotto,A.
  TITLE     Human adenovirus type 35: nucleotide sequence and vector
            development
  JOURNAL   Gene Ther. 10 (23), 1941-1949 (2003)
   PUBMED   14528318
REFERENCE   2  (bases 1 to 543)
  AUTHORS   Gao,W., Robbins,P.D. and Gambotto,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JUL-2002) Surgery, University of Pittsburgh, 300
            Technology Drive, Pittsburgh, PA 15219, USA
REFERENCE   3  (bases 1 to 543)
  AUTHORS   Gao,W., Robbins,P.D. and Gambotto,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-NOV-2003) Surgery, University of Pittsburgh, 300
            Technology Drive, Pittsburgh, PA 15219, USA
  REMARK    Sequence update by submitter
COMMENT     On Nov 6, 2003 this sequence version replaced gi:35670771.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Human adenovirus 35"
                     /mol_type="genomic DNA"
                     /strain="ATCC VR-718; Holden"
                     /db_xref="ATCC:VR-718"
                     /db_xref="taxon:10522"
     CDS             1..543
                     /note="small T-antigen"
                     /codon_start=1
                     /product="E1b 214R protein"
                     /protein_id="AAN17472.2"
                     /db_xref="GI:38196042"
                     /translation="MEVWAILEDLRKTRQLLESASDGVSGFWRFWFASELARVVFRIK
                     QDYKQEFEKLLVDCPGLFEALNLGHQVHFKEKVLSVLDFSTPGRTAAAVAFLTFILDK
                     WIPQTHFSRGYVLDFIATALWRTWKVRKMRTILGYWPVQPLGVAGILRHPPVMPAVLE
                     EEQQEDNPRAGLDPPVEEAE"
     CDS             306..>543
                     /note="large T-antigen"
                     /codon_start=1
                     /product="E1b 494R protein"
                     /protein_id="AAN17473.1"
                     /db_xref="GI:35670776"
                     /translation="MDPADSFQQGIRFGFHSHSIVENMEGSQDEDNLRLLASAAFGCS
                     GNPEASTGHASGSGGGTARGQPESRPGPSSGGGGVADLSPELQRVLTGSTSTGRDRGV
                     KRERASSGTDARSELALSLMSRRRPETIWWHEVQKEGRDEVSVLQEKYSLEQVKTCWL
                     EPEDDWEVAIKNYAKIALRPDKQYKISRRINIRNACYISGNGAEVVIDTQDKTVIRCC
                     MMDMWPGVVGMEAVTFVNVKFRGDGYNGIVFMANTKLILHGCSFFGFNNTCVDAWGQV
                     SVRGCSFYACWIATAGRTKSQLSLKKCIFQRCNLGILNEGEARVRHCASTDTGCFILI
                     KGNASVKHNMICGASDERPYQMLTCAGGHCNMLATVHIVSHQRKKWPVFDHNVLTKCT
                     MHAGGRRGMFMPYQCNMNHVKVLLEPDAFSRMSLTGIFDMNTQIWKILRYDDTRSRVR
                     ACECGGKHARFQPVCVDVTEDLRPDHLVIARTGAEFGSSGEETD"
ORIGIN      
        1 atggaggttt gggccatttt ggaagacctt aggaagacta ggcaactgtt agagagcgct
       61 tcggacggag tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt
      121 tttaggataa aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga
      181 ctttttgaag ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt
      241 ttagactttt caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta
      301 gataaatgga tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca
      361 gcattgtgga gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg
      421 cagcctttgg gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag
      481 gaggaacagc aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag
      541 tag
//