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                    BIOINFORMATICS COLLOQUIUM
               School of Computational Sciences
                    George Mason University
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          Towards uncovering dynamics of protein interaction networks


                     Dr. Teresa M. Przytycka
             		NCBI / NLM / NIH


                 Tuesday, February 21, 2006
                             4:30 pm
           Verizon Auditorium, Prince William Campus

ABSTRACT 
A major challenge in systems biology is to understand the intricate 
network of interacting molecules. The complexity in biological systems 
arises not only from various individual protein molecules but also from 
their organization into protein complexes and functional modules. 
Recently, several groups developed computational methods to identify 
network modules and/or protein complexes in protein-protein interaction 
networks. In this talk I will describe our contribution towards the next 
step in analysis of protein-protein interaction networks – recovering 
temporal relation and overlaps between functional groups.

We develop a graph-theoretical framework which allows elucidating 
functional groups together with temporal relations between them. We 
apply our approach is to delineate pheromone signaling pathway from the 
high throughput protein-protein interaction network.

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Refreshments are served at 4:00 pm. Find the schedule and directions at
http://www.binf.gmu.edu/colloq.html