----------------------------------------------------------------------- BIOINFORMATICS COLLOQUIUM School of Computational Sciences George Mason University ----------------------------------------------------------------------- Computational Neuroanatomy: Building a Brain Neuron by Neuron Giorgio Ascoli, PhD Head, Computational Neuroanatomy Group Krasnow Institute for Advanced Study George Mason University, Fairfax, VA 22030 www.krasnow.gmu.edu/ascoli Tuesday, October 7, 2003 5:00 pm (Note Special Time) Verizon Auditorium, Building PW1, Prince William Campus The staggering complexity of the brain is continuously uncovered by modern neuroscientists at all level of active research, from molecular structure to cognitive phenomena. We propose that computational models including detailed and realistic anatomical knowledge constitute a necessary approach to investigate the relationship between structure, activity, and function in the nervous system. In this talk, we will present recent results demonstrating the fundamental role of neuronal morphology in the establishement and regulation of electrophysiological dynamics and network connectivity. In addition, we will show how stochastic models based on experimental measurements can capture the functionally relevant anatomical details of neuronal trees. This opens the possibility to construct full-blown "virtual brains" which could provide umprecedented possibilities in both neuroscience and IT research. ---------------------------------------------------------------------- Refreshments are served at 4:30 pm. Find the schedule and directions at http://www.binf.gmu.edu/colloq.html