----------------------------------------------------------------------- BIOINFORMATICS COLLOQUIUM School of Computational Sciences George Mason University ----------------------------------------------------------------------- Clinical Frontiers in Joint Replacement Research Dr. Robert Hopper Anderson Orthopaedic Research Institute Tuesday, April 18, 2006 4:30 pm Verizon Auditorium, Prince William Campus ABSTRACT Total hip replacement provides reliable pain relief and is among the most successful surgical procedures currently available. While survivorship rates among older patients routinely exceed 95% at 10 years, younger hip replacement patients are at increased risk for wear- related complications and bone loss at long-term follow-up. The Anderson Orthopaedic Research Institute (AORI) has compiled over 25 years of clinical outcome data from a single high volume joint replacement practice to better understand the factors that contribute to implant wear and its biological consequences. Using radiographic measurements from clinical x-rays and retrieved implants, AORI has quantified how implant design and patient factors influence prosthesis wear. At long-term follow-up, bone resorption mediated by wear debris can jeopardize implant stability. To better assess the three- dimensional (3D) nature of bone remodeling around an artificial implant, AORI has undertaken research using computed tomography (CT) to measure bone loss. AORI is currently working to develop 3D imaging technologies to enable visualization of bone defects and to assess the efficacy of new treatment strategies. BIOSKETCH Robert Hopper currently serves as the Director of the Anderson Orthopaedic Research Institute. He earned his BS in mechanical engineering and his MS in Engineering Mechanics, both from Virginia Tech. He completed his PhD in biomedical engineering at Duke University. ----------------------------------------------------------------------- Refreshments are served at 4:00 pm. Find the schedule and directions at http://www.binf.gmu.edu/colloq.html