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                       BIOINFORMATICS COLLOQUIUM
                    School of Computational Sciences
                        George Mason University
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            Visualization and Data Mining of Proteomic Data

                       Dr. Donald J. Johann, Jr.
                NCI-FDA Clinical Proteomics Project, NIH

                      Tuesday, September 30, 2003
                                4:30 pm
        Verizon Auditorium, Prince William Campus, Building PW1

The cause of most human disease is due to the dysfunction of protein
networks.  Although cancer is classified as a genetic disease, it is a
function of a proteomic disease. Gene mutations result in aberrant
protein activity within the cell, the cellular microenvironment, and the
serum.  Proteins dictate biological processes, and determine cellular
fates.  Changes in key signaling pathways can result in selected
cellular survival advantages.  Through the study of key signaling
pathways a wiring diagram of the cell and itUs microenvironment can be
constructed.  The true scientific goal of proteomics is the
characterization of information flow within the cell and eventually an
organism.  Information flow is determined and controlled via protein
pathways and networks.

Visualization and data mining computational tools are a major component
of the platform proteomic technologies under development at the NCI-FDA
Clinical Proteomics Project.  Specific techniques include aggregating
viewers for large multi-dimensional datasets, hybrid classifiers
involving genetic algorithms and clustering, decision trees, decision
tables, and Bayesian methods.  A major goal is the establishment of a
software framework to allow learning from this new data source.
Ultimate project goals are aimed at early detection of disease, choosing
and judging efficacy of therapy, and detecting early signs of toxicity.
Visualization and data mining techniques are focused at both serum and
tissue proteomic methods.

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Refreshments are served at 3:30pm.  Find the schedule and directions at
http://www.binf.gmu.edu/colloq.html