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                       BIOINFORMATICS COLLOQUIUM
                    School of Computational Sciences
                        George Mason University
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   Computational geometry analysis of protein structure and function
  
                            Iosif Vaisman
                       George Mason University

                        Tuesday, March 1, 2005
                              4:30 pm
               Bull Run Hall 131, Prince William Campus

Nonlocal interactions between the amino acid residues play important
role in the specificity and stability of protein structures. Methods of
computational geometry, including Delaunay tessellation, provide a
robust and effective approach for quantitative description of nonlocal
residue contacts in proteins. An empirical four-body potential derived
using Delaunay tessellation of structures from a representative protein
data set helps facilitate understanding and interpretation of
structure-sequence and structure-function correlations in proteins.


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