Promoter-specific chromatin architecture as essential element of transcription machinery. <P>
 
Evidence for the important role that chromatin plays in regulatory mechanisms of gene expression has been steadily accumulated. It appears that nucleosomes serve not just as a mere DNA packing device but also as part of various regulatory schemes in which their precise positioning along the DNA molecule is important. We will consider computational approaches to nucleosome mapping in silico, results for various types of promoters, and biological implications.