BINF 732 – Genomics

Course Time: Monday 1:30-4:10 pm
Course Location : Online using Zoom. Hybrid F2F Meeting TBA
Instructor : Saleet Jafri, 703-993-8420, sjafri@gmu.edu
Office Hours : By appointment phone or web meeting
Course Web Page : http://www.binf.gmu.edu/jafri/binf732/
Prerequisites: Computer knowledge and previous courses in biology, or permission of instructor
Textbook: Discovering Genomics, Proteomics, and Bioinformatics by Campbell and Heyer 2nd Edition
on reserve in library

Course Description:

Surveys computational tools and techniques to study whole genomes and explores biological basis of genome analysis algorithms. Topics include genome maping, comparative genomics, and functional genomics.

Grading Policy:

The course grade will be determined as follows:
                                                        90-100     A
Mid-Term Exam - 30%                80-89.9    B
Final Exam - 40%                          70-79.9    C
Final Project - 30%                       70-79.9    F

Problem sets will be assigned as homework several times during the semester. They will be due two weeks after they are assigned. The assignments will be posted on the course web page.  Late homeworks will not be accepted.

Academic Honesty Policy:

Academic dishonesty will not be tolerated. This includes cheating, plagiarism, and falsification of academic records. That being said, you can help each other out on the homework (this does not mean that you can copy each other's homework).

Important Dates (Under revision):

Monday, Janueary 24 - First Day of Class
Monday, March 7 - Take-home Mid-Term Exam Posted
Monday, March 21 - Take-home Mid-Term Exam Due
Monday, April 25 - Project Presentations - Last Day of Class
Monday, May 2 - Final Exam 1:30-4:10

Course Schedule

Lecture 1 - Introduction to Genomics - January 24, 2022
Lectuer 2 - Multiscale view of Genomics:Cardiac Calcium Signaling - January 31, 2022
Lectuer 3 - Multiscale view of Genomics:Transcription Factors - February 7, 2022
Lecture 4 - Sequencing and Annotation - February 14, 2022
Lecture 5 - Genomes of Populations - February 21, 2022
Lecture 6 - Genomic Variation - February 28, 2022
Posted March 7, 2022 - Midterm Take-home Exam
Lecture 7 - Clinical Genomics - March 7, 2022
Midterm Exam Due - March 21, 2022
Lecture 8 - Functional Genomics - March 28, 2022
Lecture 9 - Epigenomics - April 4, 2022
Lecture 10 - Agricultural Genomics - April 11, 2022
Lecture 11 - Mitochondrial Genomics - April 18, 2022
Lecture 12 - Pharmacogenomics - April 25, 2022
Final Projects Due - April 25, 2022
Final Project Presentations - April 25, 2022
Final Project Presentations - May 2, 2022
Final Exam Posted - April 25, 2022
Final Exam Due - May 16, 2022

Sage Advice: If you want to do well in course: 1) Do all the problem sets. 2) Read the text book and any other assigned reading. 3) Ask questions in class and office hours. 3) If you are having difficulty doing the problem sets, be sure to get help.  I encourage the students discussing the course material and problems, but require everyone to do the work - NO COPYING.



Saleet Jafri
Thursday, January 13, 2022