Introduction
to Protein Architecture :
The Structural Biology of Proteins
Arthur M. Lesk
CONTENTS
Chapter 1: The photosynthetic reaction centre: protein structure
in a microcosm
The
reaction centre from Rhodopseudomonas viridis
Conclusions
Chapter 2: In vivo, in vitro, in silicio
Why
study proteins?
Protein
structure and conformation
The
known protein structures
The
Protein Data Bank
The
World Wide Web
Summary
Glossary
Chapter 3: Pattern and form in protein structure
Helices
and sheets
The
hierarchical nature of protein architecture
An
album of small structures
Classification
of protein structures
Loops
Protein-ligand
interactions
Chapter 4: The varieties of protein structure
Catalogues
of protein structure
The
known structures
a-helical
proteins
B-sheet
proteins
a
+ B proteins
a
/ B proteins
Closed
B-a-B barrel structures
Irregular
structures
Conclusions
Chapter 5: Molecular evolution
Evolution
of DNA and proteins
Evolution
of protein structures
Structural
relationships among related molecules
Chapter 6: Evolution in selected protein families
Evolution
of the globins
Evolution
of serine proteinases of the chymotrypsin family
NAD-binding
domains of dehydrogenases
Chapter 7: Some proteins of the immune system
Antibody
structure
Proteins
of the Major Histocompatibility Complex
T-cell
receptors
Chapter 8: Conformational changes in proteins
Structural
changes arising from change in state of ligation
Hinge
motions in proteins
The
'helix interface shear' mechanism of conformational change
The
allosteric change in haemoglobin
Serpins:
SERine Proteinase INhibitors
Higher-level
structural changes
Appendix 1: An album for browsing
Appendix 2: Useful web sites
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