MOHSIN SALEET JAFRI

School of Computational Sciences
George Mason University
10900 University Blvd., MSN 4E3
Manassas, VA 20110

703-993-8420 (phone)
703-993-8401 (fax)
 
 

sjafri@gmu.edu

EDUCATION:

PhD in biomedical sciences, The City University of New York/The Mount Sinai School of Medicine , 2/93
MS in mathematics, Courant Institute of Mathematical Sciences, New York University , 1/89
BS in mathematics, Duke University , 5/86

EXPERIENCE:

GEORGE MASON UNIVERSITY                             6/06-present
Professor and Chair,Department of Bioinformatics and Computational Biology, College of Science;
Serve as Department Chair. Teach bioinformaticss courses.  Conduct research using mathematical models in the areas of cardiovascular physiology, cell signaling, cell energetics,

GEORGE MASON UNIVERSITY                             9/99-5/06
Associate Professor and PhD Program Director,Program in Bioinformatics and Computational Biology, School of Computational Sciences;
Serve as PhD Program Director. Teach bioinformaticss courses.  Conduct research using mathematical models in the areas of cardiovascular physiology, cell signaling, cell energetics,

UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE                   5/03-present
Adjunct Associate Professor, Medical Biotechnology Center
Performed Research in the area of computational modeling of cardiac excitation-contraction couplint.

NATIONAL INSTITUTES OF HEALTH                5/03-8/03
Adjunct Investigator, Laboratory of Cardiac Energetics , National Heart, Lung, and Blood Institute
Performed research developing computational models of cardiac energy metabolism.

THE UNIVERSITY OF TEXAS AT DALLAS                             9/99-8/02
Assistant Professor, Department of Mathematical Sciences
Teach mathematics courses with an emphasis on the applications of mathematics to medicine and biology.  Conduct research using mathematical models in the areas of cardiovascular physiology, cell signaling, cell energetics, and neurobiology.

THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE                       5/95-8/99
Whitaker Foundation Research Associate, Department of Biomedical Engineering
Consult with faculty on high performance computing/modeling projects. Teach a course on high performance computing. Conduct research and train graduate students.

UNIVERSITY OF CALIFORNIA, DAVIS                                                                  12/92-4/95
Postdoctoral Fellow, Institute for Theoretical Dynamics
Study calcium regulation, calcium waves, and buffering in Xenopus oocytes, insulin secreting beta cells in the pancreas, and hormone secreting gonadotrophs.

HEWLETT PACKARD                                                                                                  2/93-6/93
System Administration Consultant
Development and implementation of system administration procedures including workstation setup, backup procedure development, and printer setup.

MOUNT SINAI SCHOOL OF MEDICINE                                                                 9/90-12/92
System Administrator
Provide user support for and administrate computer resources in the Department of Biomathematical Sciences and the Genomic Institute.

MOUNT SINAI SCHOOL OF MEDICINE                                                                 5/89-9/90
Scientific Programmer/Analyst
Conformational analysis of proteins using combinatorial energy minimization techniques. Modeling of physiological systems. Assist with system administration tasks.

NATIONAL INSTITUTES OF HEALTH                                                                   5/87-9/87
Mathematician, Mathematics Research Branch
Studied the electrical activity of pancreatic beta cells using mathematical models.

UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE                                  5/86-5/87
Mathematical Consultant
Constructed mathematical models to study calcium regulation in cardiac myocytes for the Department of Physiology.

PUBLICATIONS:

  1. Williams, G. S., M. A. Huertas, E. A. Sobie, M. S. Jafri, and G. D. Smith. 2008. Moment closure for local control models of calcium-induced calcium release in cardiac myocytes. Biophys. J. 94(4):in press
  2. Jafri, M. S. 2007. The globalization of biotechnology. Global Studies Review. 3(3):4-5
  3. M. T. Nguyen, S. J. Dudycha, and M. S. Jafri. 2007. The effects of Ca2+ on cardiac mitochondrial energy production is modulated by Na+ and H+ dynamics. Am. J. Physiol. Cell Physiol. 292(6):C2004-2020.
  4. G. S. Williams, M. A. Huertas, E. A. Sobie, M. S. Jafri, and G. D. Smith. 2007. A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes. Biophys. J. 92:2311-2328.
  5. W. G. Fisher, P.-C. Yang, R. K. Medikonduri, and M. S. Jafri. 2006. NFAT and NFκB Activation in T Lymphocytes: A Model of Differential Activation of Gene Expression. Ann. Biomed. Eng. 34(11):1712-28.
  6. M. S. Jafri and M. Kotulska. 2006. Modeling the Mechanism of Metabolic Oscillations in Ischemic Cardiac Myocytes. J. Theor. Biol. 242(4):801-817.
  7. E. A. Sobie, S. Guatimosim, L. Gomez-Viquez, L-S. Song, H. Hartmann, M. S. Jafri and W. J. Lederer. 2006. The Ca2+ leak paradox and "rogue ryanodine receptors": SR Ca2+ efflux theory and practice. Prog. Biophys. Mol. Biol. 90:172-185.
  8. M-H. T. Nguyen and M. S. Jafri. 2005. Mitochondrial calcium signaling and energy metabolism. Ann. N. Y. Acad. Sci. 1047:127-137.
  9. M.-H. T. Nguyen and M. S. Jafri. 2005. The impact of mitochondrial Ca2+ handling on energy metabolism. Proceedings of the 2005 Conference on Computational and Mathematical Methods on Science and Engineering. 608-619.
  10. M-H. T. Nguyen, H. R. Ramay, S. J. Dudycha, and M. S. Jafri. 2004. Modeling the cellular basis of cardiac excitation-contraction coupling and energy metabolism. Part I : Part 2 Recent Research Developments in Biophysics 3(Pt. 1):125-145.
  11. M. S. Jafri and K.-H. Yang. 2004. Modeling Neuronal Calcium. Computational Neuroscience: A Comprehensive Approach ed. J. Feng. CRC Press. 75-95
  12. S. Jafri, M. K. Bashi, and S. Ellahham. 2003. Usefulness of lercanidipine, a new calcium antagonist, for systemic hypertension. Hypertension Today 1:6-10.
  13. E. A. Sobie, M. S. Jafri, and W. J. Lederer. 2003. Models of cardiac Ca2+-induced Ca2+ release and Ca2+ sparks. Understanding Calcium Dynamics: Experiments and Theory. in Lecture Notes in Physics vol 623.eds M. Falcke and D. Malchow. Springer Verlag. 97-114.
  14. Zhang, H., D. Noble, M. Cannell, C. Orchard, M Lancaster, M. R. Boyett, A.V. Holden, M. Saleet Jafri, E.A. Sobie, W.J. Lederer, S.S. Demir, A. Michailova, F. DelPrincipe, M. Egger, E. Niggli, G.L. Smith, C.M. Loughrey, N. MacQuaide, J. Dempster, and A.T. Trafford. 2003. Dynamics of cardiac intracellular Ca2+ handling – from experiments to virtual cells. International Journal of Bifurcation and Chaos 13:3535-3560.
  15. Guatimosim, S., K. W. Dilly, F. Santana, M. S. Jafri, E. A. Sobie, and W. J. Lederer. 2002. Local Ca2+ sugbakubg abd EC coupling in heart Ca2+ sparks and the regulation of the [Ca2+] transient . J. Mol. Cell. Cardiol. 34:941-050.
  16. M. Kotulska and M. S. Jafri. 2003. Modeling the mechanism of metabolic oscillations in metabolically deprived cardiac myocytes. Proceedings of the IEEE. 91(1 suppl.).
  17. Sobie, and W. J. Lederer. 2002. Local Ca2+ signaling and EC coupling in heart: Ca2+ sparks and the regulation of the [Ca2+] transient. J. Mol. Cell. Cardiol. 34:941-950.
  18. Sobie, E. A., K. W. Dilly, J. d. S. Cruz, W. J. Lederer, and M. S. Jafri. 2002. Termination of cardiac of Ca2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys. J. 83:59-78
  19. Jafri, M. S., S. J. Dudycha, and B. O'Rourke. 2001. Cardiac energy metabolism: models of cellular respiration. Ann. Rev. Biomed. Eng. 3:57-81.
  20. Rice, J. J. and M. S. Jafri. 2001. Modeling calcium handling in cardiac cells. Phil. Trans. Roy. Soc. A. 359:1143-1157.
  21. S. J. Dudycha and M. S. Jafri. 2001. Modeling regulation of the citric acid cycle. Proceedings of the Physiological Society of New Zealand. 20(suppl 1):36
  22. E. A. Sobie, W. J. Lederer, and M. S. Jafri. 2001. Modeling the mechanism of calcium sparks. Proceedings of the Physiological Society of New Zealand. 20(suppl 1):77
  23. Winslow, R. L., D. F. Scollan, A. Holmes, L. Irvine, C. Y. Yung, and M. S. Jafri. 2000. Electrophysiological modeling of cardiac ventricular function: from cell to organ. Ann. Rev. Biomed. Eng. 2:119-155.
  24. Rice, J. J., M. S. Jafri, and R. L. Winslow. 2000. Modeling short-term interval-force relations in cardiac muscle. Am. J. Physiol. 278:H913-H931.
  25. Rice, J. J., M. S. Jafri and R. L. Winslow. 1999. Modeling gain and gradedness of Ca2+ release in the functional unit of the cardiac diadic space. Biophys. J. 77:1871-1884.
  26. Haddock, P. S., W. A. Coetzee, E. Cho, H. Katoh, D. M. Bers, M. S. Jafri, and M. Artman. 1999. Sub-cellular [Ca2+] gradients during excitation-contraction coupling in newborn rabbit ventricular myocytes. Circ. Res. 84:571-586.
  27. Irvine, L. A., M. S. Jafri, and R. L. Winslow. 1999. Cardiac sodium channel markov model with temperature dependence and recovery from inactivation. Biophys. J. 76:1868-1885.
  28. Winslow, R. L., J. J. Rice, M. S. Jafri, E. Marban, and B. O'Rourke. 1999. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure II. model studies. Circ. Res. 84:571-586.
  29. M. S. Jafri. 2000. Elementary events in excitation-contraction coupling in the cardiac diadic space. Proceedings of the World Congress on Medical Physics and Biomedical Engineering.
  30. M. S. Jafri. 2000. Computational modeling of short-term interval-force relations in single cardiac myocytes. Proceedings of the World Congress on Medical Physics and Biomedical Engineering
  31. Winslow, R. L., J. J. Rice, and M. S. Jafri. 1998. Modeling the cellular basis of altered excitation-contraction coupling in heart failure. Prog. Biphys. Mol. Biol. 69:497-514.
  32. Rice, J. J., M. S. Jafri, and R. L. Winslow. 1998. Modeling short-term interval force relations in cardiac muscle. Ann. N. Y. Acad. Sci. 853:345-349.
  33. Jafri, M. S., J. J. Rice and R. L. Winslow. 1998. Cardiac calcium dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum Ca2+ load. Biophys. J. 74:1149-1168.
  34. Jafri, M. S. and J. Keizer. 1997. Agonist-induced calcium waves in oscillatory cells: a biological example of Burgers' equation. Bull. Math. Biol. 59:1125-1144
  35. Jafri, M. S. and J. Keizer. 1995. On the roles of Ca2+ diffusion, Ca2+ buffering, and the endoplasmic reticulum in IP3 induced Ca2+ release. Biophys. J. 69:2139-2153.
  36. Jafri, M. S. 1995. A theoretical study of cytosolic calcium waves in Xenopus oocytes. J. Theor. Biol. 172:209-216.
  37. Jafri, M. S. and B. Gillo. 1994. A membrane potential model with counterions for cytosolic calcium oscillations. Cell Calcium . 16:9-19.
  38. Jafri, M. S. and J. Keizer. 1994. Diffusion of IP3 , but not Ca2+ , is necessary for a class of IP3-induced Ca2+ wave trains. Proc. Natl. Acad. Sci. USA 91:9485-9489.
  39. Benham, C. J. and M. S. Jafri. 1993. Disulphide bonding patterns and protein topologies. Protein Science. 2:41-54.
  40. Vajda, S., M. S. Jafri, O. U. Sezerman, and C. Delisi. 1993. Necessary conditions for avoiding incorrect polypeptide folds in conformational search by energy minimization. Biopolymers. 33:173-192.
  41. Jafri, M. S., S. Vajda, P. Pasik, and B. Gillo. 1992. A membrane model for cytosolic calcium oscillations: a study using Xenopus oocytes. Biophys. J. 63:235-246.
  42. Jafri, M. S. 1993. A theoretical study of spatial and temporal cytosolic calcium waves. Doctoral Dissertation-The City University of New York.
  43. Jafri, M. S. 1986. Mathematical models for counter-current exchange in the rete mirabile as the filling mechanism of the fish swim bladder. Honors Thesis-Duke University.